This Tyrant was sent to Rockforth Island to kill Claire Redfield and Steve Burnside. Like many Tyrant B.O.W.s, T-078 was not easy to kill, showing immense resistance to damage and had immense strength. Claire and Steve seemingly defeated it before escaping to a plane called the C-130 Hercules. However it managed to get on the plane before a series of explosions destroyed the island base.
Steve and Claire engaged in a final battle with the monster and were able to defeat it by releasing a cargo crate from its safety harness which knocked the T-078 out of the plane with it. Containing explosives, the crate exploded, completely destroying T-078.
In The Darkside Chronicles, T-078 was destroyed when a missile was launched at him. Though T-078 was strong enough to hold the missile, his strength gave out and he was launched out of the plane with the missile.